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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SYK
All Species:
20
Human Site:
Y459
Identified Species:
44
UniProt:
P43405
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43405
NP_001128524.1
635
72066
Y459
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
H
V
Chimpanzee
Pan troglodytes
XP_520123
544
61880
L383
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
Rhesus Macaque
Macaca mulatta
XP_001100834
635
72070
Y459
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
H
V
Dog
Lupus familis
XP_850411
644
73172
Y468
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
H
V
Cat
Felis silvestris
Mouse
Mus musculus
P48025
629
71358
Y453
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
H
I
Rat
Rattus norvegicus
Q64725
629
71510
Y453
A
W
G
P
L
N
K
Y
L
Q
Q
N
R
H
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026601
613
69811
F437
E
L
G
P
L
N
K
F
L
Q
K
N
R
H
V
Frog
Xenopus laevis
NP_001083616
609
69575
F433
G
L
G
P
L
N
K
F
L
A
K
N
K
N
V
Zebra Danio
Brachydanio rerio
NP_998008
586
67629
L425
T
V
K
N
L
T
E
L
V
H
Q
V
S
M
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24145
939
104255
Y752
P
L
G
S
M
L
Q
Y
I
L
D
H
G
H
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180232
837
93621
F650
S
Q
G
A
L
L
D
F
L
Q
N
D
S
I
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.5
99
91.1
N.A.
92.1
91
N.A.
N.A.
77.4
67.7
65.9
N.A.
25.5
N.A.
N.A.
26.5
Protein Similarity:
100
85.6
99.5
94.4
N.A.
94.4
93.6
N.A.
N.A.
87.4
79
77.4
N.A.
39.9
N.A.
N.A.
40.7
P-Site Identity:
100
6.6
100
100
N.A.
93.3
80
N.A.
N.A.
86.6
60
13.3
N.A.
26.6
N.A.
N.A.
26.6
P-Site Similarity:
100
33.3
100
100
N.A.
100
86.6
N.A.
N.A.
100
86.6
33.3
N.A.
53.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
10
0
0
0
10
10
0
0
0
% D
% Glu:
46
0
0
0
0
0
19
0
0
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
28
0
0
0
0
0
0
0
% F
% Gly:
10
0
82
0
0
0
0
0
0
0
0
0
10
0
19
% G
% His:
0
0
0
0
0
0
0
0
0
19
0
10
0
64
0
% H
% Ile:
0
0
0
0
10
10
0
0
10
0
0
0
0
10
19
% I
% Lys:
10
0
19
0
0
0
64
0
0
0
19
0
10
0
0
% K
% Leu:
0
64
0
0
82
19
0
19
73
10
0
0
0
0
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
19
0
% M
% Asn:
0
0
0
19
0
64
0
0
0
0
10
64
0
10
0
% N
% Pro:
10
0
0
64
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
10
0
0
64
64
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
55
0
0
% R
% Ser:
10
0
0
10
0
0
0
0
0
0
0
0
28
0
0
% S
% Thr:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% T
% Val:
0
10
0
0
0
0
0
0
19
0
0
19
0
0
46
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
55
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _